COSEE Ocean Systems: News
An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background
Description: In this experiment researchers introduce a conditional, melanocyte-targeted allele of the most common melanoma oncoprotein, BRAFV600E, into mice carrying an inactivating mutation in the Mc1r gene (these mice have a phenotype analogous to red hair/fair skin humans). They observed a high incidence of invasive melanomas without providing additional gene aberrations or ultraviolet radiation exposure. [Source: Nature]
URL: http://dx.doi.org/10.1038/nature11624
Availability: Summary
Source: Nature
Publish Date: 11/15/2012
Reading Level: Expert
Page Length:  

<< BACK