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Melanoma is the deadliest, most aggressive form of skin cancer. While surgical treatment of early-stage melanoma leads to 90 percent cure rates, advanced melanoma is notoriously resistant to chemotherapy and has a tendency to metastasize, or spread, throughout the body. Despite the success of recent approved therapeutics to treat advanced melanoma, metastatic cancer cells inevitably evolve resistance to drugs. In a new study researchers report on the mechanics by which melanoma can evolve resistance to a powerful combination of drugs-BRAF and MEK inhibitors. [Source: The Wistar Institute]
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