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Researchers have uncovered how melanoma becomes resistant to a promising new drug combo therapy utilizing BRAF+MEK inhibitors in patients after an initial period of tumor shrinkage. The research team found that the melanoma cells resist the combo therapy of BRAF+MEK inhibitors by developing highly unusual genetic changes in certain key cancer genes. These changes not only mark the presence of drug resistance melanoma cells but also tell us about potential new ways to shut them off. [Source: ScienceDaily]
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