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This journal article is an introductory article to a theme issue of this journal. The theme issue arose out of a perception that while it is widely recognized that an important impact of climate change on human health is likely to be via effects on vector-borne disease (VBD) transmission, the complexity of the biological and non-biological susceptibility modifying pathways by which such effects arise and combine to influence transmission is less well understood. [Source: Philosophical Transactions of the Royal Society B | Biological Sciences]
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