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Cancer stem cells (CSCs) are a population of cancer cells that have been described in many different cancers, including skin Squamous cell carcinoma, that feed tumor growth and could be resistant to therapy thus being responsible for tumor relapse after therapy. However, still very little is known about the mechanisms that regulate CSCs functions. A new study reports the mechanisms regulating the different functions of Twist1 controlling skin tumour initiation, cancer stem cell function and tumor progression. [Source: Universite libre de Bruxelles]
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