| Description: |
Ras/extracellular signal-regulated kinase (ERK) signaling is implicated in human cancer development and progression. ERK activation also results in the expression of MAP kinase phosphatases (MKPs) that inactivate ERK. However, it is currently unclear how MKPs regulate the oncogenic potential of the Ras/ERK pathway. Using knockout mice, the authors of this journal paper identify the MKP encoded by dual-specificity phosphatase 5 (DUSP5) as both a key regulator of nuclear ERK activity and a tumor suppressor in the DMBA/TPA model of Harvey Ras (HRas)-induced skin carcinogenesis. [Source: Proceedings of the National Academy of Sciences of the United States of America]
|
 |
