COSEE Ocean Systems: News
Development of a squamous cell carcinoma mouse model for immunotoxicity testing
Description: An important component of safety assessment of new pharmaceuticals is evaluation of their potential to increase the risk of developing cancer in humans. The traditional 2-year rodent bioassay often is not feasible or scientifically applicable for evaluation of biotherapeutics. Additionally, it has poor predictive value for non-genotoxic immunosuppressive compounds. Thus, there is a need for alternative testing strategies. A novel 3-stage tumor model in syngeneic C3H/HeN mice was evaluated here to study the effects of immunosuppressive drugs on tumor promotion and progression in vivo. [Source: Journal of Immunotoxicology]
URL: http://www.tandfonline.com/doi/abs/10.3109/1547691X.2015.1045105?journalCode=iimt20
Availability: Summary
Source: Journal of Immunotoxicology
Publish Date: 3/3/2016
Reading Level: Expert
Page Length:  

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