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After reviewing 38 published studies comprising 20,126 melanomas, researchers found that less than one-third of melanomas (29 percent) arose from an existing mole, while the vast majority (71 percent) appeared on the skin as new spots. Moreover, melanomas that arose from existing moles were thinner than other melanomas, indicating that patients whose melanoma was associated with an established mole had a better prognosis than others. [Source: American Academy of Dermatology]
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