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Investigators have a potential solution for how to kill tumor cells that have metastasized to the brain. The team has developed cancer-killing viruses that can be delivered by stem cells via the carotid artery, and applied them to metastatic tumors in the brain of clinically relevant mouse models. The investigators report the elimination of metastatic skin cancer cells from the brain of these preclinical models, resulting in prolonged survival. The study also describes a strategy of combining this therapy with immune check point inhibitors. [Source: Brighamand Women's Hospital]
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